A PoTENtial Antidote: A Prohemostatic Factor Xa Variant for Reversal of Direct Oral Anticoagulants.

نویسندگان

  • James C Fredenburgh
  • Jeffrey I Weitz
چکیده

CIRCULATION RESEARCH (ISSN 0009-7330 print / 1524-4571 online) is published semimonthly for 24 total issues a year by Wolters Kluwer Health, Inc. at 14700 Citicorp Drive, Bldg 3, Hagerstown, MD 21742. Business offices are located at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103. Production offices are located at 351 West Camden Street, Baltimore, MD 21201-2436. AHA members will have online access to the journal as a benefit of membership. In the US, individuals may subscribe in print for their personal use at the annual rate of $749 for nonmembers. International: $888 for nonmembers. Online-only and other additional rates can be found online at http://lww.com/circres. AHA membership information can be found online at professional.heart.org. Periodicals postage paid at Hagerstown, MD, and additional mailing offices. POSTMASTER: Send address changes to Circulation Research, American Heart Association, Wolters Kluwer Health, Inc., PO Box 1610, Hagerstown, MD 21740. Hyperpolarized MRI of the Human Heart Cunningham et al. page 1177

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Global assays and the management of oral anticoagulation

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A PoTENtial Antidote

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Prothrombin Complex Concentrate, a General Antidote for Oral Anticoagulation

Prothrombin complex concentrate (PCC) is used for the rapid reversal of vitamin K antagonist (VKA) anticoagulation. PCC is also applicable in situations requiring rapid reversal of anticoagulation by non-vitamin K antagonist direct thrombin and factor Xa inhibitor oral anticoagulants (NOACs), thereby making PCC a general antidote for oral anticoagulation. In this chapter, the composition of dif...

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The Reversal of Direct Oral Anticoagulants in Animal Models

Several direct oral anticoagulants (DOACs), including direct thrombin and factor Xa inhibitors, have been approved as alternatives to vitamin K antagonist anticoagulants. As with any anticoagulant, DOAC use carries a risk of bleeding. In patients with major bleeding or needing urgent surgery, reversal of DOAC anticoagulation may be required, presenting a clinical challenge. The optimal strategy...

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عنوان ژورنال:
  • Circulation research

دوره 119 11  شماره 

صفحات  -

تاریخ انتشار 2016